How to interpret laboratory data:Urine analysis

Appearance and Color  The normal urine color should range from clear to dark yellow.


Abnormal
Normal
Appearance and color

The presence of
 -WBCs
- RBCs
- bacteria

- Phosphates
- Urate



Cloudiness





Appearance and Color

The normal urine color should range from clear to dark yellow.









- myoglobin
(from muscle breakdown
from seizures, cocaine, or injuries)
 hemoglobin, -





medications
- rifampin
-phenazopyridine
- phenolphthalein
- phenothiazines
foods
- beets
- carrots
- blackberries
Red-orange












pseudomonal infection


- amitriptyline
- methylene blue

Blue-green


- myoglobin or porphyrins
from porphyria or
sickle cell crisis
- Phenol poisoning

Rhubarb ingestion
Brown-black


High Specific Gravity

Low Specific Gravity

Normal Range



 Hypersthenuria
- dehydration,
- excretion of radiologic contrast media,
- congestive heart failure
- toxemia of pregnancy,
- syndrome of inappropriate    antidiuretic hormone
- increased excretion of glucose or protein greater than 2 g/day
Hyposthenuria

- chronic renal failure
- diabetes insipidus
1.005 - 1.025
Specific Gravity

Specific gravity is an indication of the ability of the kidney to concentrate
urine
Acidic
Alkaline
Normal Range


- Metabolic acidosis
- Pyrexia
- Diabetic ketosis.
- (UTIs caused
by urea-splitting organisms Proteus, Pseudomonas),
- Renal tubular acidosis,
- acetazolamide
- thiazide diuretics.
4.5 - 8
pH
Normal urine specimens are acidic.
Causes
ketones
Causes
glucosuria
Normal Range


-Diabetic -Ketoacidosis
-Starvation
-High-protein/low-Carbohydrate diets
-Alcoholism
Diabetes mellitus Cushing disease
Pancreatitis

medications
Thiazide diuretics
Steroids
Oral contraceptives
negative
Glucose and Ketones
Glucose begins to spill into urine when serum blood glucose is greater than 180 mg/dl
False-negative
False-positive

cause

Normal Range



results may occur in patients taking high doses of vitamin
C or ascorbic acid
results for blood in the urine may occur when povidone
iodine is used as a cleansing agent before urine specimen collection
infection, nephrolithiasis, malignancies, and
benign prostatic hypertrophy
negative to trace.
Blood
Blood in the urine (hematuria) may indicate urinary tract damage.7

causes
Normal ranges

Bilirubin in the urine may be associated with
- liver disease (eg, hepatitis),
- Septicemia
- obstructive biliary tract disease

Phenazopyridine
Phenothiazines
may cause a false-positive result for bilirubin in the urine
zero to trace
Bilirubin
Bilirubin in the urine usually produces a dark yellow or brown color.2 It
appears in the urine before other signs of liver dysfunction appear
Infections and/or inflammation
of the urinary tract
zero to trace
Leukocyte Esterase Positive leukocyte esterase provides an indication of WBCs in the urine

Presence of nitrites in the urine suggests colonization or infection with gram negative organisms.
negative
Nitrites
Gram-negative bacteria are capable of converting dietary nitrates into nitrites
- diabetic nephropathy - interstitial nephritis
- hypertension
- fever
- exercise
- pyelonephritis
- multiple myeloma
- lupus
- severe CHF
0 (< 30 mg/dL) to +1  (30-100 mg/dL). Repeated positive tests or proteinuria of greater than 150 mg/dL may be a marker of renal disease
Protein
Trace protein in the urine is a common clinical finding and often has no clinical
significance
 

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