How to interpret laboratory data:CBC -1

polycythemia vera  chronic obstructive  lung disease  chronic smokers  regular vigorous exercise  Live at high altitudes


Decrease
Increase
Normal ranges
CBC item
SI
Conventional
anemia of all types, particularly iron deficiency anemia
blood loss,
hemolysis,
pregnancy,
Fluid replacement increased fluid intake.

polycythemia vera
chronic obstructive
lung disease
chronic smokers
regular vigorous exercise
Live at high altitudes.

8.7-11.2 mmol/L

7.4-9.9 mmol/L
Male: 14-18g/dl

Female: 12-16g/dl
Hemoglobin(Hgb)

carrying compound
found in the RBCs






 
all types of anemias, blood loss,
hemolysis,
pregnancy,
cirrhosis, hyperthyroidism,
leukemia
Same as Hgb
Dehydration
Shock
0.39-0.50


0.33-0.45
Male: 39%-50%


Female: 33%-45%

Hematocrit (Hct)
= (packed cell volume (PCV))
the volume of blood that is occupied by RBCs

Anemias, lymphomas,
leukemia.
After puberty, females have lower RBCs and Hgb due to menstrual
bleeding.
Erythrocytosis

Polycythemia vera, high altitudes strenuous exercise
4.2-5.9 × 1012 cells/L


3.5-5.5 × 1012 cells/L
Male: 4.2-5.9 × 106 cells/mm3


Female: 3.5-5.5 × 106 cells/mm3

Red Blood Cell

serve to transport oxygen from the lungs to the body tissue
Microcytic

iron deficiency anemia,
hemolytic anemia,
lead poisoning, thalassemia
Macrocytic

folate deficiency, vitamin B12 deficiency,
alcoholism,
chronic liver disease, hypothyroidism, anorexia,
use of medications
such as
valproic acid
zidovudine
stavudine antimetabolites


76-100 fL

76-100 μm3/cell

Mean Cell Volume(MCV)

The average volume of the erythrocyte

Hypochromic
iron deficiency anemia
Hyperchromic
folate or vitamin B12 deficiency.
In hyperlipidemia
patients,
falsely elevated in specimen turbidity
26-34 pg/cell
26-34 pg/cell

Mean Cell Hemoglobin(MCH)

the average weight of hemoglobin in the RBC
iron deficiency anemia, hemolytic anemia,
lead poisoning, Thalassemia
hereditary spherocytosis

hemolytic disorder with marked heterogeneity of clinical features, ranging from an asymptomatic condition to fulminant hemolytic anemia.

320-370 g/L

32-37 g/dL

Mean Cell Hemoglobin Concentration(MCHC)
average hemoglobin concentration in the RBC

Reticulocytopenia
infectious causes, alcoholism,
renal disease (from decreased erythropoietin),
toxins,
untreated iron deficiency
Anemia,
Drug-induced bone marrow suppression
Reticulocytosis
Hemolytic anemia, hemorrhage,
Sickle cell disease.
Indicative of response to treatment of anemias secondary to iron, vitamin B12,or folate deficiency.

0.001-0.025 RBC

0.1%-2.5% of RBC

Reticulocytes

Immature RBCs formed in the bone marrow.

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