Drug-Induced Hyperkalemia

Certain medications can also make it harder for your kidneys to remove potassium. This is

particularly true if you have kidney disease or problems with the way your body handles

potassium. Some medications may increase the amount of potassium in the body.

Medications that have been linked to hyperkalemia include:
  • Antibiotics, including penicillin G and trimethoprim.
  • Azole antifungals, used to treat vaginal yeast infections and other fungal infections.
  • Blood pressure medications called angiotensin-converting enzyme (ACE) inhibitors.
  • Blood pressure medications called angiotensin-receptor blockers (ARBs), although they are less likely than ACE inhibitors to increase potassium levels.
  • Blood pressure medications called beta-blockers.
  • Herbal supplements, including milkweed, lily of the valley, Siberian ginseng, Hawthorn berries, or preparations from dried toad skin (Bufo, Chan Su, Senso).
  • Heparin, a blood thinner.
  • Nonsteroidal anti-inflammatory medications (NSAIDs).
  • Potassium supplements.
  • Potassium-sparing diuretics, including triamterene, amiloride (Midamor), andspironolactone (Aldactone).

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