statins can lower mortality from chest infection
There is a pro-inflammatory cytokines in both acute coronary syndrome (ACS) and influenza. In ACS, inflammatory changes are "superimposed on chronic underlying inflammation and pathological changes in the coronary circulation." Statins lead to a reduction in circulating levels of pro-inflammatory cytokines and improve endothelial function.
According to Infectious Diseases Resource Center epidemiological studies have found that influenza and other acute infections are associated with increased incidence of ACS, stroke, and venous thromboembolism, as well as elevations in pro-inflammatory cytokines.that is why there are investigations about the role of statin in reduction of mortality and morbidity associated with influenza episodes.
Statin Treatment of Pneumonia and Influenza
The potential utility of statins in treating pneumonia and influenza has been demonstrated in several studies. For example, statins have been found
effective in reducing rates of hospitalization and death in outpatients with community-acquired pneumonia, and some evidence also suggests utility in reducing mortality in inpatients with pneumonia.
Fedson DS. Treating influenza with statins and other immunomodulatory agents. Antiviral Res. (2013), dx.doi.org/10.1016/j.antiviral.2013.06.018.
patients on statin when admitted to the hospital with pulmonary infections if they stop statin they develop higher rates of mortality from sepsis, that might be due to rebound hypercytokinemia in comparisone with patients who continued taking statins.
Yende S, Milbrandt EB, Kellum JA, et al. Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med. 2011;39(8):1871-1878.
The effectiveness of outpatient statin treatment has not been as thoroughly examined for influenza hospitalizations and death. One large-scale 10-year retrospective cohort study of older adults found that outpatient statin use minimally, but significantly, protects against influenza morbidity. The investigators concluded that public health officials and clinicians should focus on other measures for reducing morbidity and mortality in the next influenza pandemic.
Kwong JC, Li P, Redelmeier DA. Influenza morbidity and mortality in elderly patients receiving statins: a cohort study. PLoS One. 2009;4(11):e8087.
According to Infectious Diseases Resource Center epidemiological studies have found that influenza and other acute infections are associated with increased incidence of ACS, stroke, and venous thromboembolism, as well as elevations in pro-inflammatory cytokines.that is why there are investigations about the role of statin in reduction of mortality and morbidity associated with influenza episodes.
Statin Treatment of Pneumonia and Influenza
The potential utility of statins in treating pneumonia and influenza has been demonstrated in several studies. For example, statins have been found
effective in reducing rates of hospitalization and death in outpatients with community-acquired pneumonia, and some evidence also suggests utility in reducing mortality in inpatients with pneumonia.
Fedson DS. Treating influenza with statins and other immunomodulatory agents. Antiviral Res. (2013), dx.doi.org/10.1016/j.antiviral.2013.06.018.
patients on statin when admitted to the hospital with pulmonary infections if they stop statin they develop higher rates of mortality from sepsis, that might be due to rebound hypercytokinemia in comparisone with patients who continued taking statins.
Yende S, Milbrandt EB, Kellum JA, et al. Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med. 2011;39(8):1871-1878.
The effectiveness of outpatient statin treatment has not been as thoroughly examined for influenza hospitalizations and death. One large-scale 10-year retrospective cohort study of older adults found that outpatient statin use minimally, but significantly, protects against influenza morbidity. The investigators concluded that public health officials and clinicians should focus on other measures for reducing morbidity and mortality in the next influenza pandemic.
Kwong JC, Li P, Redelmeier DA. Influenza morbidity and mortality in elderly patients receiving statins: a cohort study. PLoS One. 2009;4(11):e8087.
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