How to interpret laboratory data:Urine analysis
Abnormal
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Normal
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Appearance and
color
|
||
The
presence of
-WBCs
-
RBCs
-
bacteria
|
-
Phosphates
-
Urate
|
Cloudiness
|
Appearance and Color
The normal
urine color should range from clear to dark yellow.
|
|
- myoglobin
(from muscle
breakdown
from
seizures, cocaine, or injuries)
hemoglobin, -
|
medications
- rifampin
-phenazopyridine
- phenolphthalein
- phenothiazines
foods
- beets
- carrots
- blackberries
|
Red-orange
|
||
pseudomonal
infection
|
- amitriptyline
- methylene
blue
|
Blue-green
|
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- myoglobin or
porphyrins
from
porphyria or
sickle
cell crisis
-
Phenol poisoning
|
Rhubarb ingestion
|
Brown-black
|
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High Specific
Gravity
|
Low Specific
Gravity
|
Normal Range
|
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Hypersthenuria
- dehydration,
- excretion of
radiologic contrast media,
- congestive
heart failure
- toxemia of
pregnancy,
- syndrome of
inappropriate antidiuretic hormone
- increased
excretion of glucose or protein greater than 2 g/day
|
Hyposthenuria
- chronic renal
failure
- diabetes insipidus
|
1.005 - 1.025
|
Specific Gravity
Specific
gravity is an indication of the ability of the kidney to concentrate
urine
|
|
Acidic
|
Alkaline
|
Normal Range
|
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- Metabolic acidosis
- Pyrexia
- Diabetic ketosis.
|
- (UTIs caused
by
urea-splitting organisms Proteus, Pseudomonas),
- Renal tubular
acidosis,
- acetazolamide
- thiazide
diuretics.
|
4.5 - 8
|
pH
Normal urine
specimens are acidic.
|
|
Causes
ketones
|
Causes
glucosuria
|
Normal Range
|
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-Diabetic
-Ketoacidosis
-Starvation
-High-protein/low-Carbohydrate
diets
-Alcoholism
|
Diabetes
mellitus Cushing disease
Pancreatitis
medications
Thiazide
diuretics
Steroids
Oral
contraceptives
|
negative
|
Glucose and Ketones
Glucose begins
to spill into urine when serum blood glucose is greater than 180 mg/dl
|
|
False-negative
|
False-positive
|
cause
|
Normal Range
|
|
results may
occur in patients taking high doses of vitamin
C or ascorbic
acid
|
results for
blood in the urine may occur when povidone
iodine is used
as a cleansing agent before urine specimen collection
|
infection,
nephrolithiasis, malignancies, and
benign
prostatic hypertrophy
|
negative to
trace.
|
Blood
Blood in the
urine (hematuria)
may indicate urinary tract damage.7
|
causes
|
Normal ranges
|
|||
Bilirubin in
the urine may be associated with
- liver disease
(eg, hepatitis),
- Septicemia
- obstructive
biliary tract disease
Phenazopyridine
Phenothiazines
may cause a false-positive
result for bilirubin in the urine
|
zero to trace
|
Bilirubin
Bilirubin in
the urine usually produces a dark yellow or brown color.2 It
appears in the
urine before other signs of liver dysfunction appear
|
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Infections and/or
inflammation
of the urinary
tract
|
zero to trace
|
Leukocyte Esterase
Positive leukocyte esterase provides an indication of WBCs in the urine
|
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Presence of
nitrites in the urine suggests colonization or infection with gram negative organisms.
|
negative
|
Nitrites
Gram-negative
bacteria are capable of converting dietary nitrates into nitrites
|
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- diabetic nephropathy
- interstitial nephritis
- hypertension
- fever
- exercise
- pyelonephritis
- multiple
myeloma
- lupus
- severe CHF
|
0 (< 30 mg/dL) to +1
(30-100 mg/dL). Repeated positive
tests or proteinuria of greater than 150 mg/dL may be a marker of renal
disease
|
Protein
Trace protein in the urine is a
common clinical finding and often has no clinical
significance
|
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