Lyrica male-mediated teratogenicity





Lyrica male-mediated teratogenicity

Pregabalin is an anticonvulsant and neuropathic pain agent. Exactly how pregabalin works is not known. It is thought to bind to certain areas of the brain that help reduce seizures, nerve pain, and anxiety.
Treating fibromyalgia or nerve pain caused by certain conditions (eg, shingles, diabetic nerve problems, spinal cord injury). It is also used in combination with other medicines to treat certain types of seizures.
Men being treated with pregabalin should be informed of the potential risk of male-mediated teratogenicity. Animal studies have reported increased incidences of:
  • specific skull alterations attributed to abnormally advanced ossification, 
  • retarded ossification, 
  • increased incidences of skeletal malformations, 
  • decreased fetal body weights, 
  • visceral variations. 
When offspring were tested as adults, neurobehavioral abnormalities and reproductive impairment were observed.

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