Pharmacology Refresh Cards: Noradrenaline - Norepinephrine

Noradrenaline  -  norepinephrine
Drug name
Sympathomimetic   (Vasopressor)
Group
Stimulates alpha-receptors in arterial and venous beds and beta1 receptors of heart, resulting in peripheral vasoconstriction and stimulation of heart rate and contractility. Coronary vasodilation occurs secondary to enhanced myocardial contractility.
Mechanism of action
duration
Interval
dose
Uses

Cont. infusion
0.01–0.4 µg/kg/min IV infusion via a central vein         
Septic shock ,with low SVR
Severe hypertension may occur if noradrenaline is given to patients taking tricyclic antidepressants since tricyclics block the uptake of noradrenaline into nerve endings.
Drug interaction
Bradycardia
Hypertension
Arrhythmias
Myocardial ischaemia
peripheral ischaemia
Side effects
Hypovolaemic shock
Acute myocardial ischaemia or MI
Contraindication & precaution
Pregnancy: Category D
Special populations
Norepinephrine may lose potency in normal saline solution
Administer in D5W or 5% dextrose in saline
If extravasation occurs, infiltration with phentolamine
Administration notes
4mg/4ml amp
Availability in pharmacy

Other notes

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